Products related to Specificity:
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Ligand-Binding Basics : Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity
A concise and accessible textbook covering ligand-binding theory in chemistry, biology, and drug development In Ligand-binding Basics: Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity, accomplished chemist Jannette Carey introduces ligand binding in a thorough and practical way for those new to the topic, as well as anyone seeking a connection between theory and experiment.Using a minimum of mathematical formalism, this book offers analytical rigor while remaining accessible to non-specialist practitioners.It provides readers with the skills they need to analyze their own binding data or published results, helping them develop an intuitive grasp of ligand-binding phenomena integrated with structural and thermodynamic understanding.Topics covered include: Application of the principles of equilibrium, mass action, and mass balance to derive the basic equations that describe all binding processesRecommended approaches for plotting and graphical analysis of binding dataStrategies for designing, analyzing, interpreting, and troubleshooting experiments from the perspective of ligand-binding theoryReview of selected examples that illustrate integration of structural and thermodynamic analysis Perfect for students and educators in chemistry, biochemistry, molecular biology, and pharmaceutical science, Ligand-binding Basics will also appeal to practitioners who aim to study ligand binding in any molecular system.
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New Experimental Probes for Enzyme Specificity and Mechanism : Volume 685
New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more. Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more.
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Autobiographical Memory Specificity and Psychopathology : A Special Issue of Cognition and Emotion
It has been repeatedly demonstrated that depression and reported history of trauma are associated with a difficulty in retrieving specific autobiographical memories, a phenomenon called overgeneral memory (Williams & Broadbent, 1986).Over the past twenty years there has been a stimulating progression in knowledge in this field, and it is clear that the topic has a considerable level of importance, both from a theoretical and clinical perspective.This Special Issue is intended to further advance this field which lies at the heart of the cognition-emotion interface.Papers published in this Issue address key issues relating to the underlying mechanisms and aetiology of overgeneral autobiographical memory, providing a state-of-the-art and pushing the field forward.
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Co-Designing Infrastructures : Community Collaboration for Liveable Cities
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What are substrate specificity and activity specificity using the example of restriction enzymes?
Substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. In the case of restriction enzymes, they have substrate specificity for particular DNA sequences, known as recognition sites. For example, the restriction enzyme EcoRI recognizes and binds to the DNA sequence GAATTC. Activity specificity, on the other hand, refers to the specific chemical reaction that an enzyme catalyzes. In the case of restriction enzymes, their activity specificity is to cleave the DNA at specific recognition sites. For example, EcoRI cleaves the DNA at the GAATTC sequence. In summary, substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule, while activity specificity refers to the specific chemical reaction that the enzyme catalyzes. In the case of restriction enzymes, they have substrate specificity for specific DNA sequences and activity specificity to cleave the DNA at those sequences.
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What is the actual difference between catalytic specificity and substrate specificity in enzymes?
Catalytic specificity refers to the ability of an enzyme to catalyze a specific chemical reaction, while substrate specificity refers to the ability of an enzyme to bind to a specific substrate. In other words, catalytic specificity is about the type of reaction that an enzyme can catalyze, while substrate specificity is about the specific molecule that an enzyme can bind to and act upon. Enzymes can have different levels of specificity for both their catalytic activity and their substrate binding, which allows them to carry out specific functions in the cell.
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What is the substrate specificity of enzymes?
The substrate specificity of enzymes refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. Enzymes are highly specific in their interactions with substrates, as they have active sites that are uniquely shaped to accommodate specific substrates. This specificity ensures that enzymes only catalyze specific reactions and do not interact with other molecules in the cell. Substrate specificity is crucial for the efficiency and regulation of biochemical reactions in living organisms.
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What is the group specificity of enzymes?
Group specificity of enzymes refers to the ability of an enzyme to act on a specific functional group within a substrate molecule. This means that the enzyme can only catalyze a reaction involving a particular functional group, such as an alcohol or an amine. Enzymes with group specificity are highly selective and only interact with substrates that contain the specific functional group that they are designed to act upon. This specificity is important for the regulation and control of biochemical pathways in living organisms.
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Paul and His Colleagues : Identity, Collaboration, and Community
Trevor Burke considers Paul’s colleagues and their different relationships with Paul, whether as equals, subordinates, and whether well-known or obscure, tracing how Paul refers to those with whom he associated in his letters.Burke examines these different figures in Paul’s life in depth, including the remarkably large number of women mentioned, and shows how they played key roles through a range of activities in helping establish and maintain Paul’s communities, including, preaching, teaching, visiting, baptizing, and the co-authoring of his letters. Burke employs a sociolinguistic approach to understand Paul’s social relations, arguing that the language Paul uses in his letters is the means whereby he constructs his social network.That is, Paul does not need to use a title (e.g., ‘apostle’) to indicate his role and function or that of his colleagues; rather, he ‘grammaticalizes’ social relations in his letters through his deliberate choice of lexeme (e.g., proper noun) and syntax (e.g., secondary clause) which signifies the value and contribution—and at times disapproval—of those with whom he joined forces.
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Psychological Interventions from Six Continents : Culture, Collaboration, and Community
This book presents psychological assessment and intervention in a cultural and relational context.A diverse range of contributors representing six continents and eleven countries write about their therapeutic interventions, all of which break the traditional assessor-as-expert-oriented framework and offer a creative adaptation in service delivery.A Collaborative/Therapeutic Assessment model, including work with immigrant communities, and Indigenous modalities underscore individual and collective case illustrations highlighting equality in the roles of the provider and the receiver of services.The universality and uniqueness of culture are explored as a construct and through case material.Some chapters describe a partnership with a Eurocentric scientific model, while others adopt a purely community method, preserved with Indigenous language and subjective methodology.This volume brings together diverse therapeutic collaborative ideas, and recognizes relational, community, and cultural psychologies as integral to mainstream assessment and intervention literature.This book is essential for psychologists and clinicians internationally and graduate students.
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The Michiana Potters : Art, Community, and Collaboration in the Midwest
A new pottery tradition has been developing along the border of northern Indiana and southern Michigan.Despite the fact that this region is not yet an established destination for pottery collectors, Michiana potters are committed to pursuing their craft thanks to the presence of a community of like-minded artists.The Michiana Potters, an ethnographic exploration of the lives and art of these potters, examines the communal traditions and aesthetics that have developed in this region.Author Meredith A. E. McGriff identifies several shared methods and styles, such as a preference for wood-fired wares, glossy glaze surfaces, cooler colors, the dripping or layering of glazes on ceramics that are not wood-fired, the handcrafting of useful wares as opposed to sculptural work, and a tendency to borrow forms and decorative effects from other regional artists.In addition to demonstrating a methodology that can be applied to studies of other emergent regional traditions, McGriff concludes that these styles and methods form a communal bond that inextricably links the processes of creating and sharing pottery in Michiana.
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Community Partnerships with School Libraries : Creating Innovative Learning Experiences
Providing a treasury of community partnership opportunities and resources for innovative learning experiences, this title helps Future Ready Librarians to create authentic, student-centered experiences that address American Association of School Librarians (AASL) standards. As school librarians strive to become Future Ready and meet the new AASL standards, community partnerships can help them to build innovative programs within their districts to realize their school's mission and goals. Placing value on the importance of preparing students for the future, this book encourages librarians to "learn, leap, and grow" and form community partnerships to create learning experiences both in and outside of school.Innovative learning experiences can have a positive impact on student engagement, empathy, knowledge, skills, and local and global awareness.This book introduces ideas, materials, resources, and a step-by-step action plan while highlighting how learning experiences meet AASL standards.A user-friendly and invaluable resource for librarians who desire to be Future Ready, it will catapult librarians to the forefront of their practice and support them as they create innovative learning experiences for their students.
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What is the biosubstrate specificity of bonds?
The biosubstrate specificity of bonds refers to the ability of enzymes to selectively bind to specific substrates and catalyze specific chemical reactions. Enzymes have specific active sites that are complementary to the shape and chemical properties of their substrates, allowing them to form temporary bonds and facilitate the conversion of substrates into products. This specificity is crucial for the regulation of biochemical pathways and the overall functioning of biological systems. It ensures that the right reactions occur at the right time and in the right place within the cell.
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What is the specificity of enzymes on substrates?
Enzymes are highly specific in their interactions with substrates, meaning that each enzyme typically catalyzes a specific chemical reaction with a specific substrate. This specificity is due to the unique three-dimensional shape of the enzyme's active site, which is complementary to the shape and chemical properties of its specific substrate. The enzyme-substrate interaction is often compared to a lock and key, where the enzyme (lock) can only bind to its specific substrate (key) due to their precise matching shapes and chemical properties. This specificity ensures that enzymes can efficiently catalyze specific reactions without interfering with other cellular processes.
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What does the term cell type specificity mean?
Cell type specificity refers to the unique characteristics and functions of a particular type of cell within an organism. It means that certain cells are specialized to perform specific tasks or functions within the body, and they have distinct molecular and structural features that enable them to carry out these functions. This specificity allows for the coordination and regulation of various physiological processes within the organism, as different cell types can perform their specialized roles in a coordinated manner. Understanding cell type specificity is important for studying the development, function, and dysfunction of different tissues and organs in the body.
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Could you please provide an urgent response regarding specificity of action?
Specificity of action refers to the ability of a treatment or intervention to target a particular problem or condition without affecting other parts of the body. It is important to consider the specificity of action when choosing a treatment to ensure that it effectively addresses the intended issue without causing unnecessary side effects or harm to other areas. It is also important to consult with a healthcare professional to determine the most appropriate and specific treatment for a particular condition.
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